Superintendent院长介绍

院长张宏吉医师

在美国生殖医学年会演讲的照片

过去的传统不孕症治疗，最为人所诟病的便是通常需要注射大量的排卵针剂，不仅造成身体的负担，也带给不孕症患者心理上的庞大压力。事实上，过多的排卵针剂刺激，除了易引发Ovarian hyperstimulation syndrome (OHSS:卵巢过度刺激症候群)外，所得到的卵子品质也是一个大问号。近年来研究发现，过度的排卵针剂及药物刺激，更有造成卵巢癌及乳癌的风险。自然周期与温和刺激疗法可以说是一种顺应人体自然排卵机制的助孕方法。相较于传统不孕症治疗，本疗法不需利用药物过度刺激卵巢来大量增加可抽取的卵子数目，只育成必要的卵子数量，因此不但可减少疗程中的药剂种类与用药剂量，降低对身体所造成的负担，经由身体自然筛选出来的少数卵子，在品质方面也较为优良。

近年来，由于社会文化与价值观的演进，现代女性往往因为工作、学业以及寻找真爱等因素延后结婚生子时机，到3、40岁才开始准备生儿育女，但从女性正常生理机能来看，最佳的黄金生育年龄却落在23-34岁！伴随着这样”生育高龄化”现象而来的往往便是必须面对难孕、不孕甚至是新生儿健康等问题。由于目前并无有效延缓人体器官老化的医学科技，一旦卵巢功能退化，难以取得健康卵子甚至是濒临停经的不排卵情况，即便有再卓越的人工生殖技术，也不免有巧妇难为无米之炊之憾！因此，利用玻璃化快速冷冻方法，让时间暂停，将健康卵子冻结在黄金时期，做为未来计画生育之用，为晚孕的新时代女性或是有必须进行特殊医疗需求的女性带来新”生”机，也提供了未来幸福人生的保障。

2003年纽约大学生殖医学中心的Dr.Noyes赴义大利访问了慢速冷冻专家Dr.Porcu后，决心在NYU生殖医学中心发展人类卵子冷冻技术，便将这个大任交付于当时专任科学家的张宏吉医师以及来自中国的复制猫熊专家刘辉。然而相较于精子、胚胎冷冻技术已行之有年，当时卵子冷冻仍有难以突破的障碍，使得张宏吉医师迟迟不敢接受这项请求。面对NYU生殖医学中心主任Dr.Grifo与Dr.Noyes的再三请托，张宏吉医师终于下定决定挑战这项艰难的任务。
在2005年，人类卵子冷冻技术开发的成功案例被报导在美国全国公司电视NBC TV。
并且在2002年至2007年间，连续六年在人类生殖领域的最高权威，美国生殖医学学会发表了13篇的研究论文报告。

日本国内日报发行量第二名的朝日新闻于2013年以全版面介绍本院。
本院于2014年接受日本TBS频道「NEWS 23」新闻节目采访，该节目针对在本院借卵之日本患者进行贴身采访制作专题报导。
2016年，位于日本广岛报社所发行的报纸「中国新闻」亦大幅报导本院借卵治疗成果，一时之间蔚为话题。
2017年登上亚洲第一大报「读卖新闻」头条新闻，报导日本人来台湾宏孕生殖医学中心治疗受赠卵子情况。显现日媒重视日人到台治疗情况并大幅报导。

张宏吉医师的学经历

  • 1986-1993 台大医学系
  • 1995-2001 台大医院妇产部
  • 2001-2007 美国纽约大学医学院生殖医学中心专任全职科学家
  • 现任 宏孕诊所院长 ＆ 台大医院妇产部兼任主治医师

张宏吉医师的研究成果

2018年最新发表论文刊登于Molecular Biology of the Cell期刊

  • Yi Liao, Hung-Chi Chang et al.(2018,Molecular Biology of the Cell) Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.(10 Oct 2018)论文浏览及下载

被Nature杂志引用

               Nature Cell Biology 的論文 Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. 引用了張宏吉醫師的論文

  • Jing Chen, Simona Torcia, Fang Xie, Chih-Jen Lin, Hakan Cakmak, Federica Franciosi, Kathleen Horner, Courtney Onodera, Jun S. Song, Marcelle I. Cedars, Miguel Ramalho-Santos, and Marco Conti.( 2013) Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013 December ; 15(12): 1415–1423. doi:10.1038/ncb2873. 論文瀏覽及下載
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2005). Developmental incompetency of denuded mouse oocytes undergoing maturation in vitro is ooplasmic in nature and is associated with aberrant Oct-4 expression. Hum Reprod , 1958–1968. 論文瀏覽及下載

学术论文

  • Chang HC, Grifo J, McCaffrey, Krey LC, Noyes N. (2007 ASRM) Using certain commercially available glass-bottomed dish with paraffin oil impacts the embryonic development of oocytes. [Abstract] Fertility & Sterility. 2007; 88: S310 (#J0130599).
  • Chang, HC; Liu, H; Noyes, N; Meng, L; Krey, L; Grifo, J. “Down regulatory effects of retinoid signaling on murine and human embryonic Oct-4 gene expression [Abstract]”. Fertility & sterility. 2006; 86: S219 (#J0123967)
  • Noyes, N; Chang, HC; Liu, H; Labella, P; Meng, L; Grifo, JA. “Presence of meiotic spindle predicts embryo competence following oocyte cryopreservation [Abstract]”. Fertility & Sterility. 2006; 86: S64 (#J0123958) Chang, HC; Noyes, N; Lee, TL; Chin, A; Krey, L; Grifo, J. “Independent and sequential expression of Oct3A and Oct3B transcription factors in human preimplantation embryos [Abstract]”. Fertility & Sterility. 2006; 86: S220 (#J0123968)
  • Chang, HC; Grifo, J; Labella, P; Ampeloquio, E; Adler, A; Krey, L. “Oct3A and Oct3B immunostaining patterns in human 3PN zygotes and aneuploid embryos diagnosed by preimplantation genetic diagnosis (PGD): Embryonic chromosome status can be independent of developmental competence [Abstract]”. Fertility & Sterility. 2006; 86: S220 (#J0123969)
  • Keegan DA, Krey LC, Chang HC and Noyes N. (2007) Increased risk of pregnancy-induced hypertension between in young recipients of oocyte donation. Fertility and Sterility. Apr;87(4):776-81.
  • Chang, HC; Liu, H; Zhang, J; Grifo, J; Krey, LC. “Ooplasnnic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation [Abstract]”. Fertility & Sterility. 2004; 82: S10 (#J0078695)
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2005) Developmental incompetency of denuded mouse oocytes undergoing maturation in vitro is ooplasmic in nature and is associated with aberrant Oct-4 expression. Human Reproduction, July, Vol. 20, No.7, 1958-1968.
  • Chang, HC; Liu, H; Zhang, J; Grifo, J; Krey, LC. “Ooplasnnic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation [Abstract]”. Fertility & Sterility. 2004; 82: S10 (#J0078695)
  • Liu H, Chang HC, Zhang J, Grifo J, Krey LC. Metaphase II nuclei generated by germinal vesicle transfer in mouse oocytes support embryonic development to term. Human Reproduction, 2003 Sep;18(9):1903-1907.
  • Chang HC, Liu H, Blaszczyk A, Grifo J, Krey LC (2003) Influences of mouse strain and culture media on in vitro maturation and embryogenesis of denuded mouse oocytes. Fertility and Sterility, Vol.80 3S S266. (#J0101655)
  • Liu H, Krey LC, Zhang J, Chang HC, Grifo JA (2002) Germinal vesicle xeno-transfer between mouse and human oocytes: a model to study ooplasmic influences on meiotic division. Fertility and Sterility, September Vol.76 No. 3S O-202.
  • Chang HC, Liu H, Grifo JA, Krey LC (2002) Influences of Gonadotroping stimulation on in vitro maturation and embryogenesis of denuded mouse oocytes. Fertility and Sterility, September Vol.76 No. 3S P-458.
  • Chang HC, Wu MY, Ho HN, Yang YS (1996) Delayed delivery of surviving triplet after fetal reduction and spontaneous abortion. Journal of Formos Medical Association. Nov;95(11):881-4. (original paper)

美国生殖医学年会演讲

  • Noyes N, Chang HC, Labella P, McCaffrey C, Fino E, Grifo J. (2007 ASRM) Visualization of meiotic spindle predicts usefulness of female gamates in an oocyte cryopreservation program.
  • Chang HC, Grifo J, McCaffrey, Krey LC, Noyes N. (2007 ASRM) Using certain commercially available glass-bottomed dish with paraffin oil impacts the embryonic development of oocytes.
  • Chang HC, Grifo J, Ampeloquio E, LaBella P, Adler A and Krey LC. (2006 ASRM) Oct3A and Oct3B immunostaining patterns in human 3PN zygotes and aneuploid embryos diagnosed by preimplantation genetic diagnosis (PGD): embryonic chromosome status can be independent of developmental competence.
  • Chang HC, Noyes N, Lee TL, Chin A, Krey LC and Grifo JA. (2006 ASRM) Independent and sequential expression of Oct3A and Oct3B transcription factors in human preimplantation embryos.
  • Chang HC, Liu H, Noyes N, Meng L, Krey LC and Grifo J. (2006 ASRM) Down regulatory effects of retinoid signaling on murine and human embryonic Oct-4 gene expression. Liu H, Labella P, Chang HC, Noyes N, Krey LC and Grifo JA. (2006 ASRM) Vitrification influence on the viability of human and mouse oocytes is temperature relevant.
  • Grifo J, Labella P, Licciardi F, Chang HC, Liu H and Noyes N. (2006 ASRM) Clinical results of an oocyte cryopreservation program. Noyes N, Chang HC, Meng L, Liu H, Labella P, Grifo J (2006 ASRM) Presence of meiotic spindle predicts embryo competence following oocyte cryopreservation.
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2005 SRM) Vitrification of metaphase II oocytes impacts Oct-4 expression during subsequent preimplantation development. Oral presentation in Montreal, 61th Annual Meeting of the American Society for Reproductive Medicine.
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2004 ASRM) Ooplasmic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation. Oral presentation in Philadelphia, 60th Annual Meeting of the American Society for Reproductive Medicine.
  • Chang HC, Liu H, Blaszczyk A, Grifo JA, Krey LC (2003 ASRM) Influences of mouse strain and culture media on in vitro maturation and embryogenesis of denuded mouse oocytes. Fertility and Sterility, Vol.80 3S S266.
  • Chang HC, Liu H, Grifo J, Krey LC (2002 ASRM) Influences of gonadotropin stimulation on in vitro maturation and embryogenesis of denuded mouse oocytes. Poster presentation in Orlando, 59th Annual Meeting of the American Society for Reproductive Medicine.
  • Liu H, Krey LC, Zhang J, Chang HC, Grifo JA (2002 ASRM) Germinal vesicle xeno-transfer between mouse and human oocytes: a model to study ooplasmic influences on meiotic division. Fertility and Sterility, September 2002 Vol.76 No. 3S O-202. 58th Annual Meeting of the American Society for Reproductive Medicine.

张宏吉医师登上NBC新闻NYU纽约大学生殖医学中心冷冻卵子报导

日本TBS节目拍摄台湾宏孕生殖医学中心治疗日本不孕夫妻专题