Superintendent院長紹介

創設者　院長張宏吉医師

アメリカ生殖医学年会演説

アメリカにて7年間不妊治療の最先端技術を研究した生殖医学と不妊症のエキスパートです

院長張宏吉医者

宏孕ARTクリニックは海外の不妊症治療専門クリニックの中で日本からの患者様が一番多いクリニックです。
院長の張宏吉は、アメリカ‧ニューヨーク大学(NYU Fertility Center)で6年間常勤科学者を務め不妊治療の最先端技術を研究した生殖医学と不妊症の専門家です。当院の治療レベルはニューヨークや東京と同じレベルで、信頼のおける治療を受ける事が出来ます。これまでにおよそ300名が当院で卵子提供治療を受けられ、そのうち7割以上の200名以上が日本人の患者様です。当院の妊娠率は75％強、出産及び妊娠継続率は60％を上回ります。

2005年には、人類卵子凍結技術発展の成功事例が全米NBC TVで報道され、張医師が卵子紡錘体検査を行う映像が何度も現れました。センター在任期間2002-2007年の間に、人類生殖分野最高権威・アメリカ生殖医学会(ASRM)で6年続けて12編の研究論文を発表し、また学術会議でも講演を多数行いました。

2013年には朝日新聞で当院が一面で紹介されました。
その後2014年にはＴＢＳニュース23の取材を受け、当院で卵子提供治療を受けた日本人の患者様の密着取材の様子が放送されました。
2016年には中国新聞でも当院の卵子提供治療の成果が大きく取り上げられ、大変話題となりました。
2017年には読売新聞の一面で台湾の卵子提供治療の現状が紹介され、当院院長の紹介及び当院で治療を受けられた患者様の体験談が掲載されました。

張宏吉医者の経歴

  • 1986-1993 台湾大学医学部卒業

  • 1995-2001 台大医院産婦人科

  • 2001-2007 米国ニューヨーク大学病院の生殖医療センター研究員

  • 現在 ホンジクリニック院長 ＆ 台湾大学付属病院産婦人科講師

張宏吉医者の研究成果

張宏吉院長の研究者としての最新の論文がMolecular Biology of the Cellにて発表されました

  • Yi Liao, Hung-Chi Chang et al.(2018,Molecular Biology of the Cell) Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.(10 Oct 2018)

雑誌Natureに引用されました

雑誌Nature Cell Biologyの論文Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.に張宏吉医者の論文を引用されました。

  • Jing Chen, Simona Torcia, Fang Xie, Chih-Jen Lin, Hakan Cakmak, Federica Franciosi, Kathleen Horner, Courtney Onodera, Jun S. Song, Marcelle I. Cedars, Miguel Ramalho-Santos, and Marco Conti.( 2013) Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013 December ; 15(12): 1415–1423. doi:10.1038/ncb2873. Download
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2005). Developmental incompetency of denuded mouse oocytes undergoing maturation in vitro is ooplasmic in nature and is associated with aberrant Oct-4 expression. Hum Reprod , 1958–1968. Download
  •  

学術論文

  • Chang HC, Grifo J, McCaffrey, Krey LC, Noyes N. (2007 ASRM) Using certain commercially available glass-bottomed dish with paraffin oil impacts the embryonic development of oocytes. [Abstract] Fertility & Sterility. 2007; 88: S310 (#J0130599).
  • Chang, HC; Liu, H; Noyes, N; Meng, L; Krey, L; Grifo, J. “Down regulatory effects of retinoid signaling on murine and human embryonic Oct-4 gene expression [Abstract]”. Fertility & sterility. 2006; 86: S219 (#J0123967)
  • Noyes, N; Chang, HC; Liu, H; Labella, P; Meng, L; Grifo, JA. “Presence of meiotic spindle predicts embryo competence following oocyte cryopreservation [Abstract]”. Fertility & Sterility. 2006; 86: S64 (#J0123958) Chang, HC; Noyes, N; Lee, TL; Chin, A; Krey, L; Grifo, J. “Independent and sequential expression of Oct3A and Oct3B transcription factors in human preimplantation embryos [Abstract]”. Fertility & Sterility. 2006; 86: S220 (#J0123968)
  • Chang, HC; Grifo, J; Labella, P; Ampeloquio, E; Adler, A; Krey, L. “Oct3A and Oct3B immunostaining patterns in human 3PN zygotes and aneuploid embryos diagnosed by preimplantation genetic diagnosis (PGD): Embryonic chromosome status can be independent of developmental competence [Abstract]”. Fertility & Sterility. 2006; 86: S220 (#J0123969)
  • Keegan DA, Krey LC, Chang HC and Noyes N. (2007) Increased risk of pregnancy-induced hypertension between in young recipients of oocyte donation. Fertility and Sterility. Apr;87(4):776-81.
  • Chang, HC; Liu, H; Zhang, J; Grifo, J; Krey, LC. “Ooplasnnic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation [Abstract]”. Fertility & Sterility. 2004; 82: S10 (#J0078695)
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2005) Developmental incompetency of denuded mouse oocytes undergoing maturation in vitro is ooplasmic in nature and is associated with aberrant Oct-4 expression. Human Reproduction, July, Vol. 20, No.7, 1958-1968.
  • Chang, HC; Liu, H; Zhang, J; Grifo, J; Krey, LC. “Ooplasnnic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation [Abstract]”. Fertility & Sterility. 2004; 82: S10 (#J0078695)
  • Liu H, Chang HC, Zhang J, Grifo J, Krey LC. Metaphase II nuclei generated by germinal vesicle transfer in mouse oocytes support embryonic development to term. Human Reproduction, 2003 Sep;18(9):1903-1907.
  • Chang HC, Liu H, Blaszczyk A, Grifo J, Krey LC (2003) Influences of mouse strain and culture media on in vitro maturation and embryogenesis of denuded mouse oocytes. Fertility and Sterility, Vol.80 3S S266. (#J0101655)
  • Liu H, Krey LC, Zhang J, Chang HC, Grifo JA (2002) Germinal vesicle xeno-transfer between mouse and human oocytes: a model to study ooplasmic influences on meiotic division. Fertility and Sterility, September Vol.76 No. 3S O-202.
  • Chang HC, Liu H, Grifo JA, Krey LC (2002) Influences of Gonadotroping stimulation on in vitro maturation and embryogenesis of denuded mouse oocytes. Fertility and Sterility, September Vol.76 No. 3S P-458.
  • Chang HC, Wu MY, Ho HN, Yang YS (1996) Delayed delivery of surviving triplet after fetal reduction and spontaneous abortion. Journal of Formos Medical Association. Nov;95(11):881-4. (original paper)

アメリカ生殖医学年会演説

  • Noyes N, Chang HC, Labella P, McCaffrey C, Fino E, Grifo J. (2007 ASRM) Visualization of meiotic spindle predicts usefulness of female gamates in an oocyte cryopreservation program.
  • Chang HC, Grifo J, McCaffrey, Krey LC, Noyes N. (2007 ASRM) Using certain commercially available glass-bottomed dish with paraffin oil impacts the embryonic development of oocytes.
  • Chang HC, Grifo J, Ampeloquio E, LaBella P, Adler A and Krey LC. (2006 ASRM) Oct3A and Oct3B immunostaining patterns in human 3PN zygotes and aneuploid embryos diagnosed by preimplantation genetic diagnosis (PGD): embryonic chromosome status can be independent of developmental competence.
  • Chang HC, Noyes N, Lee TL, Chin A, Krey LC and Grifo JA. (2006 ASRM) Independent and sequential expression of Oct3A and Oct3B transcription factors in human preimplantation embryos.
  • Chang HC, Liu H, Noyes N, Meng L, Krey LC and Grifo J. (2006 ASRM) Down regulatory effects of retinoid signaling on murine and human embryonic Oct-4 gene expression. Liu H, Labella P, Chang HC, Noyes N, Krey LC and Grifo JA. (2006 ASRM) Vitrification influence on the viability of human and mouse oocytes is temperature relevant.
  • Grifo J, Labella P, Licciardi F, Chang HC, Liu H and Noyes N. (2006 ASRM) Clinical results of an oocyte cryopreservation program. Noyes N, Chang HC, Meng L, Liu H, Labella P, Grifo J (2006 ASRM) Presence of meiotic spindle predicts embryo competence following oocyte cryopreservation.
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2005 SRM) Vitrification of metaphase II oocytes impacts Oct-4 expression during subsequent preimplantation development. Oral presentation in Montreal, 61th Annual Meeting of the American Society for Reproductive Medicine.
  • Chang HC, Liu H, Zhang J, Grifo J, Krey LC. (2004 ASRM) Ooplasmic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation. Oral presentation in Philadelphia, 60th Annual Meeting of the American Society for Reproductive Medicine.
  • Chang HC, Liu H, Blaszczyk A, Grifo JA, Krey LC (2003 ASRM) Influences of mouse strain and culture media on in vitro maturation and embryogenesis of denuded mouse oocytes. Fertility and Sterility, Vol.80 3S S266.
  • Chang HC, Liu H, Grifo J, Krey LC (2002 ASRM) Influences of gonadotropin stimulation on in vitro maturation and embryogenesis of denuded mouse oocytes. Poster presentation in Orlando, 59th Annual Meeting of the American Society for Reproductive Medicine.
  • Liu H, Krey LC, Zhang J, Chang HC, Grifo JA (2002 ASRM) Germinal vesicle xeno-transfer between mouse and human oocytes: a model to study ooplasmic influences on meiotic division. Fertility and Sterility, September 2002 Vol.76 No. 3S O-202. 58th Annual Meeting of the American Society for Reproductive Medicine.