研究成果が世の中から認められる時、それは科学者として一生で最も誇りに思える瞬間です。

 

張院長は2001年にアメリカニューヨーク大学にて常勤研究員に就任、

2005年には国際的な季刊誌にて学術論文を発表。

“Developmental incompetency of denuded mouse oocytes undergoing maturation

in vitro is ooplasmic in nature and is associated with aberrant Oct-4 expression”

 

ダウンロードするオリジナル記事 → 2005 Oct-4 expression. Human reproduction.

この論文は著名季刊誌[Human Reproduction]において発表、

世界的に有名な生殖医学専門家Ryuzo Yanagimachiも、

この論文によりこれまでの考え方が変わったと直筆のポストカードを院長に送りました。

 

 

近年、この論文は最も権威ある学術雑誌[ nature cell biology]掲載の

“Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes”にて引用されました。

ダウンロードするオリジナル記事 →  Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes

院長の論文はリファレンスの6番目に掲載されています。

またニューヨーク大学時代の同僚James A Grifoからもお祝いのポストカードが送られてきました。

 

この斬新な論文は最も権威ある学術雑誌[ nature cell biology]での引用以外にも、

多くの学術雑誌や教科書に収録されており、世界各国の研究者をも認める研究成果となっています。

この論文を引用している学術雑誌と教科書は下記の通りです。

 

題目	第一作者	作者國籍	投稿期刊	impact factor
自然受精及體細胞核移置兔胚之基因表現與發育潛能探討	陳建宏	台灣	台大生物科技研究所學位論文	0
单层细胞共培养对猪去卵丘卵母细胞体外成熟和孤雌发育的影响	顾晓龙	中國	《中国兽医学报》2011年 第4期 604-608页	0.661
山羊卵泡大小对卵母细胞体外发育能力的影响	吴志南	中國	《苏州大学学报：医学版》2009年 第5期 891-893页　共3页
Control of Oocyte Growth and Development by Intercellular Communication Within the Follicular Niche	Stephany El-Hayek	加拿大	Molecular Mechanisms of Cell Differentiation in Gonad Development pp 191-224	–
The Use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA	HelenaFulka	捷克	Current Topics in Developmental Biology Volume 77, 2007, Pages 187-211	4.000
A Method for Chronological Intravital Imaging of Bovine Oocytes during In Vitro Maturation	Morten R. Petersen	丹麥	Microscopy and Microanalysis 14, 549–560, 2008	1.891
Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification	Yang Yu	中國	Human Reproduction, Vol.24, No.3 pp. 649–657, 2009	5.020
OCT-4 Gene Expression Pattern In Different Grades Of Buffalo (Bubalus bubalis) Oocytes	Ch. Srinivasa Prasad	印度	Buffalo Bulletin (June 2010) Vol.29 No.2	0.104
Co-culture embedded in cumulus clumps promotes maturation of denuded oocytes and reconstructs gap junctions between oocytes and cumulus cells	Guixue Feng	中國	Zygote 21 (August), pp. 231–237.	1.053
Coculturing denuded oocytes during the in vitro maturation of bovine cumulus oocyte complexes exerts a synergistic effect on embryo development	S.R. Dey	韓國	Theriogenology 77 (2012) 1064–1077	1.986
Concanavalin-A Induces Granulosa Cell Death and Inhibits FSH-Mediated Follicular Growth and Ovarian Maturation in Female Rats	Ethel V. Velasquez	智利	Endocrinology,  2013, 154(5):1885–1896	4.159
Cyclic AMP elevating agents promote cumulus cell survival and hyaluronan-matrix stability thereby prolonging the time of mouse oocyte fertilizability	Monica Di Giacomo	義大利	The Journal of Biological Chemistry, 291 (2016), pp. 3821-3836	4.286
Developmental Potential of Selectively Enucleated Immature Mouse Oocytes Upon Nuclear Transfer	A.A. MOHAMMED	波蘭	MOLECULAR REPRODUCTION AND DEVELOPMENT 75:1269–1280 (2008)	2.316
Effects of cumulus cells on rabbit oocyte in vitro maturation	Y. Tao	中國	Journal of Animal Physiology and Animal Nutrition 92 (2008) 438–447	1.244
Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in Mice	Yong Cheng	中國	BIOLOGY OF REPRODUCTION 80, 464–472 (2009)	4.000
EVALUATION OF CONTRACEPTIVE PROPERTIES OF CILOSTAZOL (A PHOSPHODIESTERASE 3A INHIBITOR) IN MICE	Glen Laine	美國	Biomedical Sciences	–
Effect of maturation medium on in vitro cleavage of canine oocytes fertilized with fresh and cooled homologous semen	B. de A´ vila Rodrigues	巴西	Zygote 15 (February), pp. 43–53.	1.053
Injection of Mammalian Metaphase II Oocytes with Short Interfering RNAs to Dissect Meiotic and Early Mitotic Events	Manami Amanai	日本	BIOLOGY OF REPRODUCTION 75, 891–898 (2006)	3.432
Intrinsic quality of goat oocytes already found denuded at collection for in vitro embryo production	Joanna Maria Gonçalves Souza-Fabjan	法國	Theriogenology Nov;86(8 )2016 1–10	1.986
Live offspring from vitrified blastocysts derived from fresh and cryopreserved ovarian tissue grafts of adult mice	Xiaoqian Wang	澳洲	Reproduction (2009) 138 527–535	3.100
Maturation and Developmental Competence of Selectively Enucleated Germinal Vesicle Oocytes of Mammals upon nuclear transfer	Abd El-Nasser Ahmed Mohammed	英國	International Journal of Current Engineering and Technology, Vol.4, No.1 (Feb 2014)	1.274
Mechanisms contributing to the reduced developmental competence of glucosamine-exposed mouse oocytes	Cheryl J. Schelbach	澳洲	Reproduction, Fertility and Development, 2010, 22, 771–779	2.656
Morphometric assessment of in vitro matured dromedary camel oocytes determines the developmental competence after parthenogenetic activation	Islam M. Saadeldin	埃及	Theriogenology	1.986
Mouse Cumulus-Denuded Oocytes Restore Developmental Capacity Completely When Matured with Optimal Supplementation of Cysteamine, Cystine, and Cumulus Cells	Ping Zhou	中國	BIOLOGY OF REPRODUCTION 82, 759–768 (2010)	3.432
Paracrine factors from cumulus-enclosed oocytes ensure the successful maturation and fertilization in vitro of denuded oocytes in the cat model	Natasha M. Godard, M.Sc.	美國	Fertility and Sterility Vol. 91, No. 5, Supplement, May 2009	4.373
Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts	Dandan Liu	中國	Reproduction, Fertility and Development	2.656
Recovery of Functional Oocytes from Cultured Premeiotic Germ Cells After Kidney Capsule Transplantation	Bo Chen	中國	STEM CELLS AND DEVELOPMENT Volume 22, Number 4, 2013	3.562
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes	Jing Chen	美國	NATURE CELL BIOLOGY VOLUME 15 NUMBER 12  DECEMBER 2013	20.06
Spatial and temporal distribution of Oct-4 and acetylated H4K5 in rabbit embryos	Chien-Hong Chen	台灣	Reproductive BioMedicine Online (2012) 24, 433– 442	3.249
The beneficial effects of cumulus cells and oocyte-cumulus cell gap junctions depends on oocyte maturation and fertilization methods in mice	Cheng-Jie Zhou	中國	Peer J. 2016;4:e1761.	2.177
The uterine environment modulates trophectodermal POU5F1 levels in equine blastocysts	Y. H. Choi	美國	Reproduction (2009) 138 589–599	3.100
無卵丘水牛卵母細胞體外成熟方法的初步探討	冯貴雪	中國	畜牧獸醫學報 2007, 38(6):614~619	0.593

 

4年という短いアメリカ滞在中に医学界を震撼させる研究成果を発表。

張院長こそがあなたが探し求める医師と言えるでしょう。